Ms. Masters has practiced civil rights law for thirteen years in both private firm and non–profit settings. Her practice focuses on civil rights litigation including housing discrimination based on race, disability, sexual orientation, or source of income; impact litigation seeking to protect and advance fair housing rights; the rights of people with disabilities, including access to places of public accommodation, housing, employment, architectural barriers and physical accessibility issues, program accessibility, reasonable accommodations, and other areas of disability rights law; and police use of excessive force and other official misconduct.

She has litigated a number of complex civil rights cases on behalf of individuals and groups, including high impact civil rights cases against the New York State Department of Health, the New York State Office of Mental Retardation and Developmental Disabilities, and the New York City Police Department.

Ms. Masters worked for eight years at New York Lawyers for the Public Interest (NYLPI), a non–profit civil rights firm where she served as both the Director of the Access to Health Care program (a racial justice practice) and the Director of the Opportunity & Access program (a disability rights practice). She supervised attorneys and other staff engaged in a range of activities including impact litigation, administrative advocacy, direct representation, lobbying, community organizing, and outreach. She also served as co–counsel on the landmark Willowbrook de–institutionalization class action for a number of years.

Prior to NYLPI, Amanda was an associate at a firm focused on police misconduct and other civil rights issues, and a staff attorney at a legal services organization focused on immigrants' rights. She also served as Program Director for the Center for New York City Neighborhoods, a non–profit organization providing funding to free legal services providers and housing counseling organizations in New York City. She has served as the Treasurer of the National Police Accountability Project (NPAP), she is the Executive Vice–President of Sisterhood Mobilized for AIDS/HIV Research and Treatment (SMART), and she is the founder of the New York City Policing Roundtable (NYCPR) and serves on its Advisory Board. Ms. Masters has taught numerous Continuing Legal Education courses on the topics of police misconduct law, the rights of people with disabilities, and community organizing.