Ms. Masters has litigated civil rights matters in New York City since 1997. Her practice includes housing discrimination, employment discrimination, disability rights, and police use of excessive force and other official misconduct.

She has litigated a number of complex civil rights cases on behalf of individuals and groups, including high impact civil rights cases against the New York State Department of Health, the New York State Office of Mental Retardation and Developmental Disabilities, and members of the New York City Police Department. She served as co-counsel on the Willowbrook class action, a case brought on behalf of over 5,000 formerly institutionalized New Yorkers to ensure their right to live in community settings and receive high quality services. Ms. Masters was the 2010 recipient of the "Outstanding Fair Housing Attorney" Acting For Justice Award by the Fair Housing Justice Center.

Ms. Masters previously served as Director of Programs at New York Lawyers for the Public Interest (NYLPI), a non-profit civil rights firm. She supervised attorneys and other staff engaged in a range of activities including impact litigation, administrative advocacy, individual client representation, lobbying, and community organizing, in the areas of disability rights, access to health care, and environmental justice. Prior to NYLPI, Amanda was an Associate at a firm focused on police misconduct and other civil rights issues, and a Staff Attorney at a legal services organization focused on immigrants' rights. She also served as Program Director for the Center for New York City Neighborhoods (CNYCN), a start-up non-profit organization created by city government and philanthropy to provide funding to non-profit legal services providers and housing counseling organizations during the foreclosure crisis. She has served as the Treasurer of the National Police Accountability Project (NPAP), she is the Executive Vice-President of Sisterhood Mobilized for AIDS/HIV Research and Treatment (SMART), and she is the founder of the New York City Policing Roundtable (NYCPR) and serves on its Advisory Board. Ms. Masters has taught numerous Continuing Legal Education courses on the topics of police misconduct law, the rights of people with disabilities, and community organizing.